Largest Human Services charities by reported annual revenue

Ask why a human services charity sits near the top of this list and the answer is usually structural, not operational: it is a national federation whose filing bundles revenue from dozens of local affiliates delivering food, shelter, and case management on the ground. A single neighborhood food pantry runs at a fraction of that scale because it serves a fraction of the geography. The ranking counts only organizations with published annual figures, so many local providers, and those in countries with lighter reporting rules, are absent from the data rather than ranked behind. Size reflects reach, not care quality.

Largest Human Services charities by reported annual revenue

Ranked by reported annual revenue, of the organizations with published figures. Size is a fact, not a recommendation.

  1. 1. Mastercard Foundation 🇨🇦 19,528,087,267
  2. 2. Feeding America 🇺🇸 5,047,685,550
  3. 3. Northwestern University 🇺🇸 4,177,750,770
  4. 4. Sanofi-Aventis Patient Assistance Foundation 🇺🇸 4,149,829,881
  5. 5. Lilly Cares Foundation Inc 🇺🇸 4,057,297,889
  6. 6. American National Red Cross 🇺🇸 3,916,983,933
  7. 7. Genentech Patient Foundation 🇺🇸 3,708,338,423
  8. 8. Bristol-Myers Squibb Patient Assistance Foundation Inc 🇺🇸 2,723,409,730
  9. 9. AIDS Healthcare Foundation 🇺🇸 2,193,782,492
  10. 10. National Collegiate Athletic Association 🇺🇸 1,293,598,274
  11. 11. Presence Chicago Hospitals Network 🇺🇸 1,232,354,302
  12. 12. Southeastern Conference 🇺🇸 1,108,919,128
  13. 13. Australian Red Cross Society 🇦🇺 1,090,174,000
  14. 14. The Evangelical Lutheran Good Samaritan Society 🇺🇸 1,014,495,873
  15. 15. Inland Counties Regional Center Inc 🇺🇸 1,008,645,741
  16. 16. Lokahi Assurance Ltd 🇺🇸 967,547,788
  17. 17. Southwest Key Programs Inc 🇺🇸 921,510,747
  18. 18. Navigate Affordable Housing Partners Inc 🇺🇸 919,273,953
  19. 19. Pharmacy4humanity 🇺🇸 878,407,307
  20. 20. Regional Center of the East Bay Inc 🇺🇸 832,236,530
  21. 21. San Diego Imperial Counties Developmental Services Inc 🇺🇸 820,842,529
  22. 22. Community Care Inc 🇺🇸 807,551,599
  23. 23. South Central L a Reg Central for Dvlopmntly Disabled Persons Inc 🇺🇸 762,106,410
  24. 24. San Andreas Regional Center 🇺🇸 758,139,009

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See also: how to choose a human services charity.